From physical simulation to deployable scientific measurement

Turn difficult microscopy measurements into validated software.

NeuralSoftX builds controlled synthetic datasets from calibrated generators, trained models, scientific software and complete instrument-specific workflows for electron microscopy.

For microscope developers, scientific-software teams and industrial laboratories that need reliable results beyond standard analysis tools.

Workflow connecting an atomistic specimen model, electron microscope, detector measurement and quantitative reconstruction

What you can buy

Defined scientific deliverables—not an unexplained generic model.

Choose one component or commission the complete workflow. Every delivery states its supported operating domain, validation evidence and known limits.

Data

Controlled synthetic-data package

Microscopy observations, exact labels or targets and metadata produced by a generator calibrated across an agreed specimen–instrument–acquisition domain.

How data generation works

Model

Trained model and inference package

Task-specific weights, executable inference, deployment variants, validation evidence and documented applicability limits.

Training and model selection

Software

Reconstruction or measurement software

Classical, neural or hybrid software for correction, registration or quantitative analysis. New tomography, ptychography and phase-recovery systems are scoped as development partnerships while their validation continues.

Reconstruction capabilities

Problems NeuralSoftX solves

When the measurement matters but standard tools are not enough.

The strongest fit is a repeated, high-value workflow with representative experimental data, a clear decision criterion and an expensive technical bottleneck.

01

Ground truth is scarce or unavailable

Generate controlled observations and exact targets when experimental pairs are expensive, subjective or physically unobservable.

Synthetic data and simulation
02

Generic models fail after acquisition changes

Define and validate the supported microscope, detector, specimen, signal and acquisition domain instead of assuming visual similarity is sufficient.

Instrument-specific development
03

Noise, distortion or incomplete data blocks measurement

Restore, register or reconstruct low-dose images, distorted scans, focal series, tilt series and diffraction measurements using task-appropriate inverse methods.

Correction and reconstruction
04

Expert analysis cannot scale

Localise, segment, prioritise or quantify particles, defects, phases and other defined structures with review and failure handling built into delivery.

Measurement and analysis
05

A research method must become operational software

Package the accepted method for the required CPU or GPU, image size, latency, memory, confidentiality and integration environment.

Deployment and handover

Benefits to your organisation

Scientific control with a practical route into use.

The objective is not a convincing demonstration. It is a reproducible method that supports the required decision under real acquisition and deployment constraints.

Evidence

Develop without abundant labels

Use controlled synthetic targets to reduce dependence on manual annotation or unavailable experimental truth.

Reliability

Know where the method applies

Receive documented specimen, instrument, acquisition and deployment coverage with explicit failure and out-of-domain analysis.

Operations

Reduce repetitive expert work

Automate defined restoration, reconstruction or analysis stages while retaining review paths for uncertain or exceptional cases.

Confidentiality

Keep sensitive data under control

Support local, offline or on-premise execution when raw experimental measurements must remain in the client environment.

How a project moves

From measurement problem to accepted delivery.

The commercial process stays understandable at this level. The detailed scientific workflow, evidence separation and model-development options are available on the Expertise page.

  1. 01

    Define

    Agree the required measurement, operating domain, constraints and acceptance criteria.

  2. 02

    Build evidence

    Calibrate the generator, produce controlled data and establish classical or physical references.

  3. 03

    Develop and validate

    Compare suitable classical, neural and hybrid candidates, then test held-out experimental measurements.

  4. 04

    Deploy and accept

    Package the selected solution with operating limits, validation results and handover material.

Ways to engage

Use existing technology or build what is missing.

The scope depends on the existing evidence, required coverage and whether new simulation, algorithms, training or integration are needed.

General

Documented solution

A concrete existing package used within its stated evidence domain, where its ownership and licence permit delivery.

Instrument-adapted

Calibrated to the measurement

Existing NeuralSoftX-controlled technology adapted and validated against a client's representative measurement domain.

Custom

New measurement workflow

New generators, inverse methods, architectures, interfaces or integrations for a previously unsupported problem.

Technology in active development

New reconstruction systems are being implemented and validated.

NeuralSoftX is independently developing and packaging complete tomography and electron-ptychography workflows, together with a neural exit-wave reconstruction system.

These capabilities can be discussed for development partnerships and remain separate from validated off-the-shelf delivery.

See development status
Electron tomography workflow connecting tilted specimen measurements and projections to a matching three-dimensional reconstruction

Selected evidence

Established research behind a young company.

Open-source software, peer-reviewed computational methods and industrial delivery experience support the work without turning previous institutional research into a company-owned claim.

Physical simulation

MULTEM

C++/CUDA multislice simulation for electron diffraction, imaging and spectroscopy, used as a foundation for simulation-backed method development.

View on GitHub

Restoration

tk_r_em

Published simulation-trained single-shot restoration across SEM, STEM and TEM with deployable ONNX inference.

View on GitHub

Scientific machine learning

rt_ppiscs

A learned surrogate for real-time ADF-STEM scattering-cross-section prediction within a defined parameter range.

View on GitHub

Start with the measurement

What must your microscopy workflow detect, correct, reconstruct or quantify?

Discuss the problem